منابع مشابه
Studies on Antigenic Competition
Antigenic competition was studied in a haptenic system. It was found that: (a) The extent of competition is greater when larger doses of antigen are employed. (b) Antigenic competition appears to be independent of the carrier molecule. (c) The affinity of the antibody produced in antigenic competition is approximately equal to the affinity of antibody formed by animals immunized with only one a...
متن کاملFurther Studies of Antigenic Competition
A striking correlation between the capacity of an antigen to nonspecifically suppress humoral immune responses of subsequently administered antigens which are non-cross-reacting, i.e. to manifest antigenic competition and produce enlargement of spleen size through cell proliferation, was found. Increase in spleen size was always accompanied by a drop in the normal proportion of thymus-derived c...
متن کاملQuantitative Studies on Antigenic Recognition
Lymphoid cells from normal animals from two genetically alien but isogenic strains of mice or rats elaborated a factor into the medium during in vitro cultivation. Similarly, lymphoid cells from specifically presensitized animals mixed and cultivated with donor-type lymphoid cells, as well as normal or specifically immunized mouse spleen cells exposed to heterologous red blood cell antigens, fo...
متن کاملStudies on the Antigenic Properties of Complement
Sheep erythrocytes sensitized with amboceptor and persensitized thereafter with guinea pig complement are agglutinated by rabbit anti-guinea pig globulin and by immune sera obtained by injection of rabbits with fixed complement. In this agglutination neither C'1 nor C'2 takes part. Fixed C'4 acts as an agglutinogen. An additional agglutinogen, distinct from C'4, was found on persensitized cells...
متن کاملStudies on the Antigenic Structure of Ribonuclease
Alkali-denatured bovine pancreatic ribonuclease (RNase) reacts poorly with antibody to the native molecule, and RNase whose disulfide bridges have been broken by oxidation or reduction is completely inactive with this antiserum. These observations suggest that the antigenicity of the native protein is, in part, attributable to its conformation (1). Oxidized RNase has no detectable immunogenic o...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1969
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.130.4.821